GCK antibody - N-terminal region (ARP61473_P050) | Aviva Systems Biology ARP61473 product information

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product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

GCK antibody - N-terminal region (ARP61473_P050)

catalog :

ARP61473

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot

product information

sku :

ARP61473

product type :

Polyclonal Antibody

category :

Polyclonal

name :

GCK antibody - N-terminal region (ARP61473_P050)

size :

100 ul

gene symbol :

GCK

alias symbols :

FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, MODY2, LGLK

nucleotide accession num :

NM_033508

protein accession num :

NP_277043

swissprot id :

P35557-3

species reactivity :

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

RVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLF
DYISECISDFL
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

host :

Rabbit

application :

homology :

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Sheep: 93%

purification :

Affinity Purified

clonality :

Polyclonal

drywet surcharge :

Wet Ice

storage temperature :

-20C