PRAME antibody - N-terminal region (ARP55981_P050) | Aviva Systems Biology ARP55981 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

PRAME antibody - N-terminal region (ARP55981_P050)

catalog :

ARP55981

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

sku :

ARP55981

product type :

Polyclonal Antibody

category :

Polyclonal

name :

PRAME antibody - N-terminal region (ARP55981_P050)

size :

100 ul

gene symbol :

PRAME

alias symbols :

MAPE, OIP4, CT130

nucleotide accession num :

NM_006115

protein accession num :

NP_006106

swissprot id :

P78395

species reactivity :

Cow, Horse, Human, Mouse, Pig, Rat

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEA
LAIAALELLPR
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.

host :

Rabbit

application :

homology :

Cow: 86%; Horse: 93%; Human: 100%; Mouse: 79%; Pig: 86%; Rat: 85%

purification :

Affinity Purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME

drywet surcharge :

Wet Ice

storage temperature :

-20C