NONO antibody - N-terminal region (ARP40715_T100) | Aviva Systems Biology ARP40715 product information

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product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

NONO antibody - N-terminal region (ARP40715_T100)

catalog :

ARP40715

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunocytochemistry

product information

sku :

ARP40715

product type :

Polyclonal Antibody

category :

Polyclonal

name :

NONO antibody - N-terminal region (ARP40715_T100)

size :

100 ul

gene symbol :

NONO

alias symbols :

P54, NMT55, NRB54, P54NRB

nucleotide accession num :

NM_007363

protein accession num :

NP_031389

swissprot id :

Q15233

species reactivity :

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

KQNHTPRKHHQHHHQQQHHQQQQQQPPPPPIPANGQQAS
SQNEGLTIDLK
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.

host :

Rabbit

application :

IF, WB

homology :

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%

purification :

Protein A purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the N terminal region of human NONO

drywet surcharge :

Wet Ice

storage temperature :

-20C