PRMT2 antibody - N-terminal region (ARP40196_T100) | Aviva Systems Biology ARP40196 product information

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product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

PRMT2 antibody - N-terminal region (ARP40196_T100)

catalog :

ARP40196

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 6f	Hou W, Nemitz S, Schopper S, Nielsen M, Kessels M, Qualmann B. Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl. Dev Cell. 2018;45:262-275.e8 pubmed publisher

product information

sku :

ARP40196

product type :

Polyclonal Antibody

category :

Polyclonal

name :

PRMT2 antibody - N-terminal region (ARP40196_T100)

size :

100 ul

gene symbol :

PRMT2

alias symbols :

HRMT1L1

nucleotide accession num :

NM_001535

protein accession num :

NP_001526

swissprot id :

P55345

species reactivity :

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

ESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQL
SFLRGEKILIL
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.

host :

Rabbit

application :

IHC, WB

homology :

Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%

purification :

Protein A purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2

drywet surcharge :

Wet Ice

storage temperature :

-20C