TRPM8 antibody - N-terminal region (ARP35357_P050) | Aviva Systems Biology ARP35357 product information

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product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

TRPM8 antibody - N-terminal region (ARP35357_P050)

catalog :

ARP35357

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunohistochemistry

product information

sku :

ARP35357

product type :

Polyclonal Antibody

category :

Polyclonal

name :

TRPM8 antibody - N-terminal region (ARP35357_P050)

size :

100 ul

gene symbol :

TRPM8

alias symbols :

LTRPC6, MGC2849, TRPP8

nucleotide accession num :

NM_024080

protein accession num :

NP_076985

swissprot id :

Q7Z2W7

species reactivity :

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

YILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERT
IQDSNYGGKIP
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

host :

Rabbit

application :

IHC, WB

homology :

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%

purification :

Affinity Purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM8

drywet surcharge :

Wet Ice

storage temperature :

-20C