TRPM4 antibody - N-terminal region (ARP35268_P050) | Aviva Systems Biology ARP35268 product information

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product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

TRPM4 antibody - N-terminal region (ARP35268_P050)

catalog :

ARP35268

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot

product information

sku :

ARP35268

product type :

Polyclonal Antibody

category :

Polyclonal

name :

TRPM4 antibody - N-terminal region (ARP35268_P050)

size :

100 ul

gene symbol :

TRPM4

alias symbols :

FLJ20041, TRPM4B, PFHB1B

nucleotide accession num :

NM_017636

protein accession num :

NP_060106

swissprot id :

Q8TD43

species reactivity :

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

ELLTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDEL
RLAVAWNRVDI
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

TRPM4 is a calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. TRPM4 mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. TRPM4 is involved in myogenic constriction of cerebral arteries. It controls insulin secretion in pancreatic beta-cells. TRPM4 may also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload.

host :

Rabbit

application :

homology :

Cow: 79%; Dog: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 100%; Rat: 100%

purification :

Affinity Purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM4

drywet surcharge :

Wet Ice

storage temperature :

-20C