SIRT6 antibody - middle region (ARP32408_P050) | Aviva Systems Biology ARP32408 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

SIRT6 antibody - middle region (ARP32408_P050)

catalog :

ARP32408

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat, dogs, bovine

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

product information

sku :

ARP32408

product type :

Polyclonal Antibody

category :

Polyclonal

name :

SIRT6 antibody - middle region (ARP32408_P050)

size :

100 ul

gene symbol :

SIRT6

alias symbols :

SIR2L6

nucleotide accession num :

NM_016539

protein accession num :

NP_057623

swissprot id :

Q8N6T7

species reactivity :

Cow, Dog, Human, Rat

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

TRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHR
PPKRVKAKAVP
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

SIRT6 is a NAD-dependent protein deacetylase. SIRT6 has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. SIRT6 is required for genomic stability, normal IGF1 serum levels and normal glucose homeostasis. SIRT6 modulates cellular senescence and apoptosis. SIRT6 regulates the production of TNF protein.This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

host :

Rabbit

application :

WB, IP, CHIP

homology :

Cow: 100%; Dog: 100%; Human: 100%; Rat: 83%

purification :

Affinity Purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the middle region of human SIRT6

drywet surcharge :

Wet Ice

storage temperature :

-20C