This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody
catalog :
ABIN400824
quantity :
0.1 mg
price :
489.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3F2-H10-F2
reactivity :
human, chimpanzee
application :
western blot, immunohistochemistry, enzyme immunoassay
citations: 3
Reference
Reiser J, Polu K, Möller C, Kenlan P, Altintas M, Wei C, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005;37:739-44 pubmed
Hofmann T, Obukhov A, Schaefer M, Harteneck C, Gudermann T, Schultz G. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999;397:259-63 pubmed
D ESPOSITO M, Strazzullo M, Cuccurese M, Spalluto C, Rocchi M, D Urso M, et al. Identification and assignment of the human transient receptor potential channel 6 gene TRPC6 to chromosome 11q21-->q22. Cytogenet Cell Genet. 1998;83:46-7 pubmed
product information
Catalog Number :
ABIN400824
Product Name :
anti-Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6) (C-Term) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
TRPC6
Product Type :
Primary
Size :
0.1 mg
List Price USD :
489.5 USD
List Of Pubmed ID :
9925922,15924139,9930701
Clone :
3F2-H10-F2
Isotype :
IgG1
Product Description :
TRPC6, also known as TRP6, short transient receptor potential channel 6 and transient receptor potential cation channel subfamily C member 6, is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC6 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or Gprotein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C and may not to be activated by intracellular calcium store depletion. Defects in this gene are a cause of focal segmental glomerulosclerosis (FSGS). Expression of this protein has been reported in tissues such as placenta, lung, spleen, ovary, small intestine, and renal podocytes. Immunohistochemistry studies using polyclonal antibodies to this target have shown moderate to strong staining in cell types such as neurons, breast, respiratory, squamous and prostate epithelium, epidermis, placental trophoblasts, dendritic cells, and subsets of immune cells, and faint to moderate staining of adrenal, colon, ganglion cells, hepatocytes, heart, and testis.Synonyms: Short transient receptor potential channel 6, TRP-6, Transient receptor protein 6
Immunogen :
Synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6protein.
Epitope :
C-Term
Reactivity :
Chimpanzee,Human
Buffer :
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
Concentration :
1.0 mg/mL (by UV absorbance at 280 nm)
Application Summary :
Enzyme Immunoassay (EIA),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
Q9Y210
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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