This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody
catalog :
ABIN375024
quantity :
0.1 mg
price :
368.5 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, bovine, swine
application :
western blot, immunohistochemistry, enzyme immunoassay
product information
Catalog Number :
ABIN375024
Product Name :
anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) (Internal Region) antibody
Host Species :
Goat
Clonality :
Polyclonal
Antigen :
DNMT1
Product Type :
Primary
Size :
0.1 mg
List Price USD :
368.5 USD
List Of Pubmed ID :
18252747
Product Description :
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt 1, Dnmt 2 and Dnmt 3. Dnmt 1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt 2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt 3a and Dnmt 3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F 1, and HDAC 1. Dnmt 1 also cooperates with Rb to repress transcription from promoters containing E2F binding sites suggesting a link between DNA methylation, histone deacetylase and sequence specific DNA binding activity, as well as a growth regulatory pathway that is disrupted in nearly all cancer cells.Synonyms: AIM, CXXC-type zinc finger protein 9, CXXC9, DNA (cytosine-5)-methyltransferase 1, DNA methyltransferase HsaI, HsaI, MCMT
Immunogen :
Peptide with sequence from the internal egion of the protein sequence Genename: DNMT1
Epitope :
Internal Region
Reactivity :
Cow (Bovine),Dog (Canine),Human,Mouse (Murine),Pig (Porcine),Rat (Rattus)
Buffer :
Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
Concentration :
0.5 mg/mL
Application Summary :
Enzyme Immunoassay (EIA),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
P26358
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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