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product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) (C-Term) antibody
catalog :
ABIN374435
quantity :
0.1 mg
price :
368.5 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, enzyme immunoassay
product information
Catalog Number :
ABIN374435
Product Name :
anti-Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) (C-Term) antibody
Host Species :
Goat
Clonality :
Polyclonal
Antigen :
GAPDH
Product Type :
Primary
Size :
0.1 mg
List Price USD :
368.5 USD
List Of Pubmed ID :
22564186,18556354,18286188,17517966,18296432,20489048,24526161
Product Description :
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a metabolic enzyme originally thought to be only involved in Glycolysis. GAPDH is constitutively expressed at high levels in almost all tissues and serves therefore as a useful marker for the measurement of equal loading in western blotting experiments. Because of its ubiquitous expression, GAPDH is often seen as a housekeeping gene. However in the last two decades, every year a new function for this enzyme has been revealed. Besides its central role as a cytoplasmic enzyme in Glycolysis, recent evidence suggests that mammalian GAPDH is also involved in a great number of intracellular processes such as DNA replication and repair, nuclear membrane fusion, endocytosis, nuclear translocation in apoptosis, microtubule bundling, vesicular secretory transport, maintenance of telomere structure, phosphotransferase activity and nuclear RNA export. We now know that GAPDH is not only in the cytoplasm, but it shuttles between the cytoplasm and the nucleus and membranes. A lot of reports demonstrate the role of GAPDH in different pathologies such as progression in prostate cancer and ovarian cancer (mRNA stability), programmed neuronal cell death, and agerelated neuronal diseases. For example the sub-cellular distribution of GAPDH is abnormal in patients with Alzheimer's disease.Synonyms: CDABP0047, GAPD, Glyceraldehyde-3-Phosphate Dehydrogenase
Immunogen :
Peptide with sequence from the C-Terminus of the protein sequence according to NP_002037.2.
Epitope :
C-Term
Reactivity :
Dog (Canine),Human,Mouse (Murine),Rat (Rattus)
Buffer :
Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Concentration :
0.5 mg/mL
Application Summary :
Enzyme Immunoassay (EIA),Immunofluorescence (IF),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
P04406
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
antibodies-online.com facilitates researchers to find the appropriate antibodies for their respective research project. As an independent and multi-vendor marketplace for research antibodies and thanks to the cooperation with more than 120 different manufacturers, we offer a large selection of Antibodies (over 500,000), ELISA Kits (over 200,000), Secondary Antibodies (13,000), Proteins (150,000), Peptides and Isotype Controls. In addition the scientists receive news and detailed information about the individual antibodies from databases such as the PubMed and others.
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