This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (Middle Region) antibody
catalog :
ABIN358745
quantity :
0.4 mL
price :
357.5 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, enzyme immunoassay
product information
Catalog Number :
ABIN358745
Product Name :
anti-WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (Middle Region) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen :
WISP1
Product Type :
Primary
Size :
0.4 mL
List Price USD :
357.5 USD
List Of Pubmed ID :
12805222,12717393,12529380,11782444,11751417
Isotype :
Ig
Product Description :
Wisp1 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. Wisp1 may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83 % identical to the mouse protein at the amino acid level.Synonyms: CCN family member 4, CCN4, WNT1-inducible-signaling pathway protein 1, Wnt-1-induced secreted protein
Immunogen :
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human WISP1.
Epitope :
Middle Region
Reactivity :
Human
Buffer :
PBS with 0.09 % (W/V) sodium azide
Concentration :
0.25 mg/mL
Application Summary :
Enzyme Immunoassay (EIA),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
O95388
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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