anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (Middle Region) antibody | Antibodies-online ABIN309632 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Antibodies-online

product type :

antibody

product name :

anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (Middle Region) antibody

catalog :

ABIN309632

quantity :

50 μg

price :

289 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human, mouse, rat, dog, chicken, cow, pig, common platanna

application :

western blot

citations: 2

Published Application/Species/Dilution	Reference
	Blount A, Vaughan J, Vale W, Bilezikjian L. A Smad-binding element in intron 1 participates in activin-dependent regulation of the follistatin gene. J Biol Chem. 2008;283:7016-26 pubmed publisher
	Blount P, Merlie J. BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor. J Cell Biol. 1991;113:1125-32 pubmed

product information

Catalog Number :

ABIN309632

Product Name :

anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (Middle Region) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen :

SMAD1

Product Type :

Primary

Size :

50 μg

List Price USD :

289 USD

List Of Pubmed ID :

2040645,18184649

Image Legend :

WB Suggested Anti-SMAD1 Antibody Titration: 0.2-1 µg/mL Positive Control: MCF7 cell lysate

Product Description :

SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

Immunogen :

Synthetic peptide directed towards the middle region of human SMAD1

Epitope :

Middle Region

Reactivity :

Chicken,Cow (Bovine),Dog (Canine),Human,Mouse (Murine),Pig (Porcine),Rat (Rattus),Xenopus laevis

Buffer :

PBS buffer with 2 % sucrose

Concentration :

1 mg/mL

Application Summary :

Western Blotting (WB)

Uniprot ID :

Q15797