This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
catalog :
ABIN238438
quantity :
0.1 mg
price :
286 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LT95
reactivity :
human
application :
immunohistochemistry, flow cytometry, FACS
citations: 6
Reference
Brumatti G, Yon M, Castro F, Bueno da Silva A, Jacysyn J, Brunner T, et al. Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide. Exp Cell Res. 2008;314:554-63 pubmed
Guo Z, Zhang M, Tang H, Cao X. Fas signal links innate and adaptive immunity by promoting dendritic-cell secretion of CC and CXC chemokines. Blood. 2005;106:2033-41 pubmed
Drosopoulos K, Roberts M, Cermak L, Sasazuki T, Shirasawa S, Andera L, et al. Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J Biol Chem. 2005;280:22856-67 pubmed
Nakamura T, Kakinuma H, Amada H, Miyata N, Taniguchi K, Koda A, et al. Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors. Bioorg Med Chem. 2004;12:6209-19 pubmed
Park D, Thomsen A, Frevert C, Pham U, Skerrett S, Kiener P, et al. Fas (CD95) induces proinflammatory cytokine responses by human monocytes and monocyte-derived macrophages. J Immunol. 2003;170:6209-16 pubmed
Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli K, et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 1998;17:1675-87 pubmed
product information
Catalog Number :
ABIN238438
Product Name :
anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
CD95 / FAS
Product Type :
Primary
Size :
0.1 mg
List Price USD :
286 USD
List Of Pubmed ID :
15519164,9501089,12794152,15941911,18078929,15757891
Clone :
LT95
Isotype :
IgG1
Product Description :
CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Immunogen :
HUT-78 human T cell lymphoma cell line
Reactivity :
Human
Buffer :
Tris buffered saline (TBS), pH 8.0, 15 mM Sodium Azide
Concentration :
1.0 mg/mL
Application Summary :
Flow Cytometry (FACS),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Uniprot ID :
P25445
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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