This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Tumor Protein P53 (TP53) (AA 378-393), (C-Term), (pSer392) antibody
catalog :
ABIN238404
quantity :
0.1 mg
price :
324.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
FP3-2
reactivity :
human
application :
western blot, immunohistochemistry
citations: 6
Reference
Tanigawa S, Fujii M, Hou D. Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells. Biosci Biotechnol Biochem. 2008;72:797-804 pubmed
Blaydes J, Craig A, Wallace M, Ball H, Traynor N, Gibbs N, et al. Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene. 2000;19:3829-39 pubmed
Taylor W, DePrimo S, Agarwal A, Agarwal M, Schonthal A, Katula K, et al. Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell. 1999;10:3607-22 pubmed
Taylor W, Agarwal M, Agarwal A, Stacey D, Stark G. p53 inhibits entry into mitosis when DNA synthesis is blocked. Oncogene. 1999;18:283-95 pubmed
Agarwal M, Agarwal A, Taylor W, Chernova O, Sharma Y, Stark G. A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides. Proc Natl Acad Sci U S A. 1998;95:14775-80 pubmed
Agarwal M, Agarwal A, Taylor W, Stark G. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci U S A. 1995;92:8493-7 pubmed
product information
Catalog Number :
ABIN238404
Product Name :
anti-Tumor Protein P53 (TP53) (AA 378-393), (C-Term), (pSer392) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
p53 (TP53)
Product Type :
Primary
Size :
0.1 mg
List Price USD :
324.5 USD
List Of Pubmed ID :
10564259,18323654,7667317,9843965,9927185,10951576
Clone :
FP3-2
Isotype :
IgG1
Product Description :
The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
Immunogen :
KLH-conjugated phosphopeptide RHKKLMFKTEGPDS[P] corresponding to amino acids378-393 representing the C-terminus of Human p53.
Epitope :
AA 378-393,C-Term,pSer392
Reactivity :
Human
Buffer :
PBS, pH ~7.4, 15 mM Sodium Azide
Concentration :
1.0 mg/mL
Application Summary :
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
P04637
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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