antibody

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) antibody

ABIN197433

50 μL

253 USD

polyclonal

domestic rabbit

nonconjugated

human, mouse, rat

western blot, immunocytochemistry

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) antibody

Rabbit

Polyclonal

Amyloid beta A4 Protein / APP

Primary

50 μL

253 USD

9870932,8313898,8131745,10936190

Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II

peptide Sequence around amino acids 666~670 (A-V-T-P-E) derived from Human APP protein.

AA 666-670

Human,Mouse (Murine),Rat (Rattus)

PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

1.0 mg/mL

Immunofluorescence (IF),Western Blotting (WB)

P05067