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product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (pTyr1214) antibody
catalog :
ABIN196769
quantity :
50 μL
price :
280.5 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
product information
Catalog Number :
ABIN196769
Product Name :
anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (pTyr1214) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen :
CD309 / VEGFR-2 / Flk-1
Product Type :
Primary
Size :
50 μL
List Price USD :
280.5 USD
List Of Pubmed ID :
14724572,11387210
Product Description :
VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Synonyms: FLK1, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2
Immunogen :
Synthetic phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 1214 (F-H-YP-D-N).
Epitope :
pTyr1214
Reactivity :
Human
Buffer :
PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Concentration :
1.0 mg/mL
Application Summary :
Immunofluorescence (IF),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
P35968
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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