This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (C-Term) antibody
catalog :
ABIN183694
quantity :
100 μg
price :
229 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat, dog, chicken, pig, zebrafish , common platanna
application :
western blot
citations: 1
Published Application/Species/DilutionReference
Jadlowiec J, Zhang X, Li J, Campbell P, Sfeir C. Extracellular matrix-mediated signaling by dentin phosphophoryn involves activation of the Smad pathway independent of bone morphogenetic protein. J Biol Chem. 2006;281:5341-7 pubmed
product information
Catalog Number :
ABIN183694
Product Name :
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (C-Term) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen :
SMAD1
Product Type :
Primary
Size :
100 μg
List Price USD :
229 USD
List Of Pubmed ID :
16326713
Image Legend :
WB Suggested Anti-SMAD1 Antibody Titration: 0.625 µg/mL ELISA Titer: 1:1562500 Positive Control: Jurkat cell lysate
Product Description :
SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Immunogen :
Synthetic peptide directed towards the C terminal of human SMAD1
Epitope :
C-Term
Reactivity :
Chicken,Dog (Canine),Human,Mouse (Murine),Pig (Porcine),Rat (Rattus),Xenopus laevis,Zebrafish (Danio rerio)
Buffer :
PBS buffer with 2 % sucrose
Concentration :
1 mg/mL
Application Summary :
Western Blotting (WB)
Uniprot ID :
Q15797
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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