anti-CD68 Molecule (CD68) antibody | Antibodies-online ABIN181837 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Antibodies-online

product type :

antibody

product name :

anti-CD68 Molecule (CD68) antibody

catalog :

ABIN181837

quantity :

0.1 mg

price :

346.5 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

FA-11

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, FACS, immunohistochemistry - frozen section

citations: 11

Reference
Zimmermann O, Homann J, Bangert A, Müller A, Hristov G, Goeser S, et al. Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis. J Am Heart Assoc. 2012;1:e003293 pubmed publisher
Lopez M, Klein A, Dimbil U, Scott M. Anatomically defined neuron-based rescue of neurodegenerative Niemann-Pick type C disorder. J Neurosci. 2011;31:4367-78 pubmed publisher
Frossard J, Lenglet S, Montecucco F, Steffens S, Galan K, Pelli G, et al. Role of CCL-2, CCR-2 and CCR-4 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. J Clin Pathol. 2011;64:387-93 pubmed publisher
Rahaman S, Swat W, Febbraio M, Silverstein R. Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. J Biol Chem. 2011;286:7010-7 pubmed publisher
Kassim S, Li H, Vandenberghe L, Hinderer C, Bell P, Marchadier D, et al. Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis. PLoS ONE. 2010;5:e13424 pubmed publisher
West E, Pearson R, Barker S, Luhmann U, MacLaren R, Barber A, et al. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cells. 2010;28:1997-2007 pubmed publisher
Kirby A, Beattie L, Maroof A, Van Rooijen N, Kaye P. SIGNR1-negative red pulp macrophages protect against acute streptococcal sepsis after Leishmania donovani-induced loss of marginal zone macrophages. Am J Pathol. 2009;175:1107-15 pubmed publisher
Schleicher U, Hesse A, Bogdan C. Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-gamma in IL-12/IL-18-stimulated mouse macrophage populations. Blood. 2005;105:1319-28 pubmed
da Silva R, Gordon S. Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein. Biochem J. 1999;338 ( Pt 3):687-94 pubmed
Ramprasad M, Terpstra V, Kondratenko N, Quehenberger O, Steinberg D. Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein. Proc Natl Acad Sci U S A. 1996;93:14833-8 pubmed
Rabinowitz S, Gordon S. Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli. J Exp Med. 1991;174:827-36 pubmed

product information

Catalog Number :

ABIN181837

Product Name :

anti-CD68 Molecule (CD68) antibody

Host Species :

Rat

Clonality :

Monoclonal

Antigen :

CD68

Product Type :

Primary

Size :

0.1 mg

List Price USD :

346.5 USD

List Of Pubmed ID :

19644016,21345872,20857496,8962141,1919437,10051440,15383459,20976059,21209086,21430138,23316321

Image Legend :

Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68 (ABIN181837).

Clone :

FA-11

Isotype :

IgG2a

Product Description :

The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. Macrosialin is the murine homologue of the human macrophage glycoprotein CD68, both are members of the lysosomal-associated membrane protein (lamp) family which are located predominantly within the cells and can be detected by flow cytometry using cell permeablisation.Synonyms: Gp110, Macrophage marker, Macrosialin

Immunogen :

Purified Concanavalin A acceptor glycoprotein from P815 cell line.

Reactivity :

Mouse (Murine)

Buffer :

PBS, pH 7.4, 0.09 % Sodium Azide

Concentration :

1.0 mg/mL

Application Summary :

Flow Cytometry (FACS),Immunofluorescence (IF),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunoprecipitation (IP),Western Blotting (WB)

Uniprot ID :

P31996