This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 154-167) antibody
catalog :
ABIN180331
quantity :
0.1 mg
price :
456.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SMP14
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section
citations: 3
Reference
Gueven N, Becherel O, Birrell G, Chen P, DelSal G, Carney J, et al. Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res. 2006;66:2907-12 pubmed
Picksley S, Vojtesek B, Sparks A, Lane D. Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene. 1994;9:2523-9 pubmed
Martin K, Trouche D, Hagemeier C, Sørensen T, La Thangue N, Kouzarides T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature. 1995;375:691-4 pubmed
product information
Catalog Number :
ABIN180331
Product Name :
anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (AA 154-167) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
MDM2
Product Type :
Primary
Size :
0.1 mg
List Price USD :
456.5 USD
List Of Pubmed ID :
16540636,8058315,7791903
Clone :
SMP14
Isotype :
IgG1
Product Description :
Human homolog of Murine Double Minute-2 (MDM2) and p53 function in mutual regulation: activation of p53 results in expression of MDM2 which consequently inhibits the ability of wild type p53 to stimulate expression of target genes. MDM2 is frequently overexpressed in the nuclei of soft tissue sarcomas, and to a much lesser extent, in a wide variety of malignancies of bladder, breast, testes, cervix, and glial cells.Synonyms: Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2
Immunogen :
A Synthetic peptide corresponding to amino acids 154-167 of human MDM2 protein. Spleen cells from immunised BALB/c mice were fused with cells of the mouse X63Ag8. 653myeloma cell line. AA Sequence: Cys-SRPSTSSRRRAISE
Epitope :
AA 154-167
Reactivity :
Human,Mouse (Murine),Rat (Rattus)
Buffer :
PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative
Concentration :
1.0 mg/mL
Application Summary :
Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunoprecipitation (IP),Western Blotting (WB)
Uniprot ID :
Q00987
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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