This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Notch 1 (NOTCH1) antibody (PE)
catalog :
ABIN120355
quantity :
100 tests
price :
286 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
mN1A
reactivity :
human, mouse
application :
flow cytometry, FACS
citations: 5
Published Application/Species/DilutionReference
Ray W, Yao M, Nowotny P, Mumm J, Zhang W, Wu J, et al. Evidence for a physical interaction between presenilin and Notch. Proc Natl Acad Sci U S A. 1999;96:3263-8 pubmed
Huppert S, Le A, Schroeter E, Mumm J, Saxena M, Milner L, et al. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000;405:966-70 pubmed
Kang-Decker N, Tong C, Boussouar F, Baker D, Xu W, Leontovich A, et al. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 2004;5:177-89 pubmed
Espinosa L, Santos S, Inglés-Esteve J, Munoz-Canoves P, Bigas A. p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR. J Cell Sci. 2002;115:1295-303 pubmed
Dass C, Choong P. Zoledronic acid inhibits osteosarcoma growth in an orthotopic model. Mol Cancer Ther. 2007;6:3263-70 pubmed
product information
Catalog Number :
ABIN120355
Product Name :
anti-Notch 1 (NOTCH1) antibody (PE)
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
PE
Antigen :
NOTCH1
Product Type :
Primary
Size :
100 tests
List Price USD :
286 USD
List Of Pubmed ID :
10879540,14998493,10077672,11884528,18089720
Image Legend :
Staining of mouse thymus with Mouse anti NOTCH1-RPE (ABIN120355)
Clone :
mN1A
Isotype :
IgG1
Product Description :
Notch1 is a single transmembrane receptor which is expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoieisis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression.Synonyms: Neurogenic locus notch homolog protein 1, Notch 1, TAN1, hN1
Immunogen :
Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1. Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
Reactivity :
Human,Mouse (Murine)
Buffer :
PBS, pH 7.4, containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Concentration :
0.1 mg/mL
Application Summary :
Flow Cytometry (FACS)
Uniprot ID :
P46531
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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