This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) (AA 376-390) antibody
catalog :
ABIN120192
quantity :
1 mL
price :
929.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H4
reactivity :
human, mouse, rat, chicken, bovine, swine, domestic sheep, domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry
citations: 15
Reference
Schicht M, Ernst J, Nielitz A, Fester L, Tsokos M, Guddat S, et al. Articular cartilage chondrocytes express aromatase and use enzymes involved in estrogen metabolism. Arthritis Res Ther. 2014;16:R93 pubmed publisher
Wu Y, Bennett J, Talla D, Stocco C. Testosterone, not 5?-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells. Mol Endocrinol. 2011;25:656-68 pubmed publisher
Lu Y, Kang T, Hu Y. BRCA1/BARD1 complex interacts with steroidogenic factor 1--A potential mechanism for regulation of aromatase expression by BRCA1. J Steroid Biochem Mol Biol. 2011;123:71-8 pubmed publisher
Horling K, Santos A, Fischer B. The AhR is constitutively activated and affects granulosa cell features in the human cell line KGN. Mol Hum Reprod. 2011;17:104-14 pubmed publisher
Bender R, Zhou L, Wilkars W, Fester L, Lanowski J, Paysen D, et al. Roles of 17ß-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus. Cereb Cortex. 2010;20:2985-95 pubmed publisher
Jeong J, Jung Y, Kim H, Jin J, Kim H, Kang S, et al. The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol. 2010;30:2365-75 pubmed publisher
Zhao D, McBride D, Nandi S, McQueen H, McGrew M, Hocking P, et al. Somatic sex identity is cell autonomous in the chicken. Nature. 2010;464:237-242 pubmed publisher
Catalano S, Malivindi R, Giordano C, Gu G, Panza S, Bonofiglio D, et al. Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells. J Biol Chem. 2010;285:5581-93 pubmed publisher
Sirianni R, Chimento A, De Luca A, Zolea F, Carpino A, Rago V, et al. Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells. J Biol Chem. 2009;284:28905-16 pubmed publisher
Ghosh S, Lu Y, Hu Y. A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression. Int J Biomed Sci. 2008;4:260-265 pubmed
Colette S, Lousse J, Defrere S, Curaba M, Heilier J, van Langendonckt A, et al. Absence of aromatase protein and mRNA expression in endometriosis. Hum Reprod. 2009;24:2133-41 pubmed publisher
Barone I, Cui Y, Herynk M, Corona Rodriguez A, Giordano C, Selever J, et al. Expression of the K303R estrogen receptor-alpha breast cancer mutation induces resistance to an aromatase inhibitor via addiction to the PI3K/Akt kinase pathway. Cancer Res. 2009;69:4724-32 pubmed publisher
Carpino A, Rago V, Pezzi V, Carani C, Ando S. Detection of aromatase and estrogen receptors (ERalpha, ERbeta1, ERbeta2) in human Leydig cell tumor. Eur J Endocrinol. 2007;157:239-44 pubmed
Lu Y, Amleh A, Sun J, Jin X, McCullough S, Baer R, et al. Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells. Mol Endocrinol. 2007;21:651-63 pubmed
Turner K, MacPherson S, Millar M, McNeilly A, Williams K, Cranfield M, et al. Development and validation of a new monoclonal antibody to mammalian aromatase. J Endocrinol. 2002;172:21-30 pubmed
product information
Catalog Number :
ABIN120192
Product Name :
anti-Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) (AA 376-390) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
Aromatase
Product Type :
Primary
Size :
1 mL
List Price USD :
929.5 USD
List Of Pubmed ID :
19493871,20421250,20823264,11786371,17185394,17656605,21273442,20231365,20220842,19679653,20026603,20501638,21087664,19487288,19568323,24725461
Image Legend :
Western blot analysis of human placenta extract probed with antiI Hu Cytochrome P450 Aromatase (ABIN120192) followed by F(ab')2 Rabbit anti Mouse IgG:HRP (ABIN121365).
Clone :
H4
Isotype :
IgG2a
Product Description :
Aromatase is a key enzyme in steroidogenesis and plays an important role in sexual differentiation, oestrogen biosynthesis, fertility and carcinogenesis. It is highly conserved amongst mammals, and is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity and thereby disrupt endocrine function.Synonyms: ARO1, CYAR, CYP19, CYP19A1, CYPXIX, Cytochrome P450 19A1, Estrogen synthetase, P450AROM
Immunogen :
Synthetic peptide corresponding to amino acids 376-390 of Human Aromatase.
Epitope :
AA 376-390
Reactivity :
Baboon,Chicken,Cow (Bovine),Human,Marmoset,Monkey,Mouse (Murine),Pig (Porcine),Rabbit,Rat (Rattus),Sheep (Ovine)
Buffer :
0.09 % Sodium Azide
Application Summary :
Immunofluorescence (IF),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
P11511
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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