anti-CD3 (CD3) (Cytoplasmic Domain) antibody | Antibodies-online ABIN119451 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Antibodies-online

product type :

antibody

product name :

anti-CD3 (CD3) (Cytoplasmic Domain) antibody

catalog :

ABIN119451

quantity :

0.2 mg

price :

731.5 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

CD3-12

reactivity :

chicken, swine

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS, immunohistochemistry - frozen section

citations: 10

Reference
Hong M, Puaux A, Huang C, Loumagne L, Tow C, MacKay C, et al. Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control. Cancer Res. 2011;71:6997-7009 pubmed publisher
Osorio Y, Travi B, Renslo A, Peniche A, Melby P. Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system. PLoS Negl Trop Dis. 2011;5:e962 pubmed publisher
Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, et al. B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes. J Immunol. 2010;184:4819-26 pubmed publisher
Gendronneau G, Lemieux M, Morneau M, Paradis J, Tetu B, Frenette N, et al. Influence of Hoxa5 on p53 tumorigenic outcome in mice. Am J Pathol. 2010;176:995-1005 pubmed publisher
Patole P, Pawar R, Lech M, Zecher D, Schmidt H, Segerer S, et al. Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice. Nephrol Dial Transplant. 2006;21:3062-73 pubmed
Herrmann I, Kellert M, Schmidt H, Mildner A, Hanisch U, Bruck W, et al. Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2. Infect Immun. 2006;74:4841-8 pubmed
Kapturczak M, Wasserfall C, Brusko T, Campbell Thompson M, Ellis T, Atkinson M, et al. Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol. 2004;165:1045-53 pubmed
Shulga Morskaya S, Dobles M, Walsh M, Ng L, Mackay F, Rao S, et al. B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J Immunol. 2004;173:2331-41 pubmed
Burudi E, Marcondes M, Watry D, Zandonatti M, Taffe M, Fox H. Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains. J Virol. 2002;76:12233-41 pubmed
Jones M, Cordell J, Beyers A, Tse A, Mason D. Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies. J Immunol. 1993;150:5429-35 pubmed

product information

Catalog Number :

ABIN119451

Product Name :

anti-CD3 (CD3) (Cytoplasmic Domain) antibody

Host Species :

Rat

Clonality :

Monoclonal

Antigen :

CD3

Product Type :

Primary

Size :

0.2 mg

List Price USD :

731.5 USD

List Of Pubmed ID :

20308631,21948969,12414962,15331427,16954173,20042682,16861672,8515069,15294946,21358812

Image Legend :

Staining of permeabilized, human peripheral blood lymphocytes with Rat anti Human CD3 (ABIN119451).

Clone :

CD3-12

Isotype :

IgG1

Product Description :

T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4

Immunogen :

Synthetic peptide sequence derived from Cytoplasmic epitope of CD3

Epitope :

Cytoplasmic Domain

Reactivity :

Chicken,Dog (Canine),Horse (Equine),Human,Mouse (Murine),Pig (Porcine)

Buffer :

PBS, 0.09 % Sodium Azide

Concentration :

1.0 mg/mL

Application Summary :

Flow Cytometry (FACS),Immunofluorescence (IF),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)

Uniprot ID :

P07766