This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-CD4 Molecule (CD4) (Non-Polymorphic Site) antibody (FITC)
catalog :
ABIN118164
quantity :
0.1 mg
price :
198 USD
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
YTS177-9
reactivity :
mouse
application :
flow cytometry, FACS
citations: 4
Reference
Wise M, Bemelman F, Cobbold S, Waldmann H. Linked suppression of skin graft rejection can operate through indirect recognition. J Immunol. 1998;161:5813-6 pubmed
Cobbold S, Martin G, Waldmann H. The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodies. Eur J Immunol. 1990;20:2747-55 pubmed
Robinson J, Graham T, Emr S. A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Mol Cell Biol. 1991;11:5813-24 pubmed
Qin S, Wise M, Cobbold S, Leong L, Kong Y, Parnes J, et al. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol. 1990;20:2737-45 pubmed
product information
Catalog Number :
ABIN118164
Product Name :
anti-CD4 Molecule (CD4) (Non-Polymorphic Site) antibody (FITC)
Host Species :
Rat
Clonality :
Monoclonal
Conjugation :
FITC
Antigen :
CD4
Product Type :
Primary
Size :
0.1 mg
List Price USD :
198 USD
List Of Pubmed ID :
1702726,9834057,1980112,1840635
Image Legend :
Staining of mouse peripheral blood lymphocytes with RAT ANTI MOUSE CD4:FITC
Clone :
YTS177-9
Isotype :
IgG2a
Product Description :
CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1), HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1), IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin Intracellular ligands: p56Lck CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus, CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).Synonyms: T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
Immunogen :
Mouse spleen cells. Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1.2.3 rat myeloma cell line.
Epitope :
Non-Polymorphic Site
Reactivity :
Mouse (Murine)
Buffer :
PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
Concentration :
0.1 mg/mL
Application Summary :
Flow Cytometry (FACS)
Uniprot ID :
P06332
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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