This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Notch 2 (NOTCH2) (AA 2396-2409) antibody
catalog :
ABIN117999
quantity :
0.2 mL
price :
489.5 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, chimpanzee
application :
western blot, immunohistochemistry, enzyme immunoassay
product information
Catalog Number :
ABIN117999
Product Name :
anti-Notch 2 (NOTCH2) (AA 2396-2409) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen :
NOTCH2
Product Type :
Primary
Size :
0.2 mL
List Price USD :
489.5 USD
List Of Pubmed ID :
11187898,12668592
Image Legend :
Figure. Western blot using Anti-Notch 2 (intra) antibody shows detection of a band at ~110 kDa corresponding to active Notch 2 protein (arrowhead). Western Blot analysis was performed for Notch 2 expression using 100ug of total protein lysate obtained from human mesothelial SV40 cells
Product Description :
Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane. Notch functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.Synonyms: Neurogenic locus notch homolog protein 2, Notch 2, hN2
Immunogen :
A synthetic peptide corresponding to amino acid residues 2396-2409 of Human Notch 2 (the total protein is 2471 aa). A residue of cysteine was added to the amino terminal end to facilitate coupling.
Epitope :
AA 2396-2409
Reactivity :
Chimpanzee,Dog (Canine),Human,Mouse (Murine),Rat (Rattus)
Buffer :
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, containing 0.09 % sodium azide
Concentration :
75 mg/mL (by Refractometry)
Application Summary :
Enzyme Immunoassay (EIA),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)
Uniprot ID :
Q04721
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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