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product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Insulin (INS) antibody
catalog :
ABIN117970
quantity :
0.1 mg
price :
489.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2D11-H5
reactivity :
human, swine
application :
western blot, immunohistochemistry, immunoprecipitation, enzyme immunoassay, immunohistochemistry - frozen section
citations: 1
Reference
Hopkins D, Williams G. Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity. Diabet Med. 1997;14:1044-50 pubmed
product information
Catalog Number :
ABIN117970
Product Name :
anti-Insulin (INS) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
Insulin
Product Type :
Primary
Size :
0.1 mg
List Price USD :
489.5 USD
List Of Pubmed ID :
9455932
Image Legend :
Diagram of Insulin Structure. Insulin is a polypeptide hormone produced by cells in the islets of Langerhans in the pancreas. Insulin decreases the levels of glucose in the blood and regulates the metabolism of glucose, fats and proteins. In order to meet the demand for insulin needed by diabetics, the hormone is mass-produced with the aid of genetically engineered bacteria, but can also be taken from pigs and cattle. The diagram to the left illustrates the structure of insulin and proinsulin. Proinsulin is a single polypeptide chain of 86 amino acids that permits correct alignment of three pairs of disulfide bonds. Insulin is derived from proinsulin by cleavage of the C-peptide structure at the dipeptides Arg-Arg and Lys-Arg. Insulin is composed of an A chain of 21 amino acids and a B chain of 30 amino acids, the chains being held together by two disulfide bonds. A third disulfide bond is present within the A chain.
Clone :
2D11-H5
Isotype :
IgG1
Product Description :
Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-peptide basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain acids. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as β-cell and tumor (insulinoma) markers.Synonyms: INS
Immunogen :
Purified human Insulin coupled to Bovine Serum Albumin (BSA).
Reactivity :
Human,Pig (Porcine)
Buffer :
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None
Concentration :
1.0 mg/mL (by UV absorbance at 280 nm)
Application Summary :
Immunohistochemistry (Frozen Sections) (IHC (fro)),Enzyme Immunoassay (EIA),Immunoprecipitation (IP),Western Blotting (WB)
Uniprot ID :
P01308
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
antibodies-online.com facilitates researchers to find the appropriate antibodies for their respective research project. As an independent and multi-vendor marketplace for research antibodies and thanks to the cooperation with more than 120 different manufacturers, we offer a large selection of Antibodies (over 500,000), ELISA Kits (over 200,000), Secondary Antibodies (13,000), Proteins (150,000), Peptides and Isotype Controls. In addition the scientists receive news and detailed information about the individual antibodies from databases such as the PubMed and others.
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