This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (AA 460-480), (C-Term) antibody
catalog :
ABIN117897
quantity :
0.2 mL
price :
489.5 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay, immunohistochemistry - frozen section
product information
Catalog Number :
ABIN117897
Product Name :
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (AA 460-480), (C-Term) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen :
AKT1 / PKB
Product Type :
Primary
Size :
0.2 mL
List Price USD :
489.5 USD
List Of Pubmed ID :
11686294,11356119
Image Legend :
Immunohistochemistry. Rabbit anti-AKT was used at a 1:1,000 dilution to detect AKT by immunohistochemistry. ,.In panel (A) normal colon tissue is stained. Panel (B) shows tumor tissue. Tissue was formalin-fixed and paraffin embedded.
Product Description :
AKT is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and rac (related to A and C kinases). AKT is a key regulator of many signal transduction pathways. AKT Exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis, (ii) promotion of proliferation.Synonyms: Akt-1, C-AKT, Protein kinase B, RAC-PK-alpha, RAC-alpha serine/threonine-protein kinase
Immunogen :
Synthetic peptide corresponding to the C-terminus (460-480) of Human, Rat and Mouse and chicken AKT proteins conjugated to KLH using maleimide. A residue of cysteine was added to the amino terminal end to facilitate coupling.
Epitope :
AA 460-480,C-Term
Reactivity :
Chicken,Human,Mouse (Murine),Rat (Rattus)
Buffer :
0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 containing 0.01 % Sodium Azide
Concentration :
85 mg/mL (by refractometry)
Application Summary :
Enzyme Immunoassay (EIA),Immunofluorescence (IF),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunoprecipitation (IP),Western Blotting (WB)
Uniprot ID :
P31749
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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