anti-Podoplanin (PDPN) antibody | Antibodies-online ABIN115146 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Antibodies-online

product type :

antibody

product name :

anti-Podoplanin (PDPN) antibody

catalog :

ABIN115146

quantity :

0.1 mg

price :

390.5 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

18H5

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS, immunohistochemistry - frozen section

citations: 8

Reference
Birke K, Lütjen Drecoll E, Kerjaschki D, Birke M. Expression of podoplanin and other lymphatic markers in the human anterior eye segment. Invest Ophthalmol Vis Sci. 2010;51:344-54 pubmed publisher
Turner J, Langley R, Johnston K, Gentil K, Ford L, Wu B, et al. Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem. 2009;284:22364-78 pubmed publisher
Conrad C, Niess H, Huss R, Huber S, von Luettichau I, Nelson P, et al. Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. Circulation. 2009;119:281-9 pubmed publisher
Riesenberg R, Weiler C, Spring O, Eder M, Buchner A, Popp T, et al. Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma. Clin Cancer Res. 2007;13:6993-7002 pubmed
Kilic N, Oliveira Ferrer L, Neshat Vahid S, Irmak S, Obst Pernberg K, Wurmbach J, et al. Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1. Blood. 2007;110:4223-33 pubmed
Schacht V, Ramirez M, Hong Y, Hirakawa S, Feng D, Harvey N, et al. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003;22:3546-56 pubmed
Zimmer G, Oeffner F, von Messling V, Tschernig T, Gröness H, Klenk H, et al. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem J. 1999;341 ( Pt 2):277-84 pubmed
Breiteneder Geleff S, Matsui K, Soleiman A, Meraner P, Poczewski H, Kalt R, et al. Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am J Pathol. 1997;151:1141-52 pubmed

product information

Catalog Number :

ABIN115146

Product Name :

anti-Podoplanin (PDPN) antibody

Host Species :

Mouse

Clonality :

Monoclonal

Antigen :

Podoplanin

Product Type :

Primary

Size :

0.1 mg

List Price USD :

390.5 USD

List Of Pubmed ID :

9327748,10393083,12853470,17761831,18056175,19737877,19118255,19458089

Image Legend :

FACS analysis of Podoplanin in human microvascular endothelial cells using antibody ABIN115146.

Clone :

18H5

Isotype :

IgG1

Product Description :

Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid (aa) precursor (NP_006465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207-228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential O-linked glycosolation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47 % aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC2). Their association is dependent on sialic acid on O-glycans of Podoplanin. Through its association with CLEC2, Podoplanin-induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.Synonyms: Aggrus, GP36, Glycoprotein 36, PA2.26 antigen, PDPN, PSEC0003, PSEC0025, T1-alpha

Immunogen :

GP36 (Podoplanin) expressed by MDCK cells.

Reactivity :

Human

Buffer :

PBS, pH 7.4 without preservatives or stabilizers

Application Summary :

Flow Cytometry (FACS),Immunofluorescence (IF),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)

Uniprot ID :

Q86YL7