This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) antibody (Biotin)
catalog :
ABIN114224
quantity :
0.1 mg
price :
253 USD
clonality :
monoclonal
host :
rat
conjugate :
biotin
clone name :
R1-2
reactivity :
mouse
application :
immunohistochemistry, flow cytometry, FACS, immunohistochemistry - frozen section
citations: 3
Reference
Berlin C, Berg E, Briskin M, Andrew D, Kilshaw P, Holzmann B, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993;74:185-95 pubmed
Holzmann B, Weissman I. Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel. EMBO J. 1989;8:1735-41 pubmed
Holzmann B, McIntyre B, Weissman I. Identification of a murine Peyer's patch--specific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4 alpha. Cell. 1989;56:37-46 pubmed
product information
Catalog Number :
ABIN114224
Product Name :
anti-Integrin, alpha 4 (Antigen CD49D, alpha 4 Subunit of VLA-4 Receptor) (ITGA4) antibody (Biotin)
Host Species :
Rat
Clonality :
Monoclonal
Conjugation :
Biotin
Antigen :
CD49d / ITGA4
Product Type :
Primary
Size :
0.1 mg
List Price USD :
253 USD
List Of Pubmed ID :
2463092,2670559,7687523
Image Legend :
Rat anti CD49d (Integrin alpha 4 chain) R1-2
Clone :
R1-2
Isotype :
IgG2b
Product Description :
Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
Immunogen :
Peyers Patch HEV binding lymphoma line (TK1) Donor: Fisher Spleen Fusion Partner: P3x63Ag8.653
Reactivity :
Mouse (Murine)
Buffer :
PBS, 0.02 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL
Concentration :
0.1 mg/mL
Application Summary :
Immunohistochemistry (Frozen Sections) (IHC (fro)),Flow Cytometry (FACS)
Uniprot ID :
Q00651
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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