This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 1-181), (N-Term) antibody
catalog :
ABIN1108474
quantity :
0.1 mg
price :
313.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N1
reactivity :
human, rat, swine
application :
western blot
citations: 3
Reference
Wang Y, Goligorsky M, Lin M, Wilcox J, Marsden P. A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase. J Biol Chem. 1997;272:11392-401 pubmed
Brenman J, Chao D, Xia H, Aldape K, Bredt D. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell. 1995;82:743-52 pubmed
Kharazia V, Schmidt H, Weinberg R. Type I nitric oxide synthase fully accounts for NADPH-diaphorase in rat striatum, but not cortex. Neuroscience. 1994;62:983-7 pubmed
product information
Catalog Number :
ABIN1108474
Product Name :
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 1-181), (N-Term) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
NOS1
Product Type :
Primary
Size :
0.1 mg
List Price USD :
313.5 USD
List Of Pubmed ID :
9111048,7545544,7531307
Clone :
N1
Isotype :
IgG1
Product Description :
Nitric Oxide Synthase 1(NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect ofendothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24.2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2.Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is thought to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal (Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.Synonyms: Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, Nitric Oxide Synthase, bNOS, nNOS
Immunogen :
Protein A fusion protein
Epitope :
AA 1-181,N-Term
Reactivity :
Goat,Human,Pig (Porcine),Rat (Rattus)
Buffer :
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Concentration :
0,1 mg/mL
Application Summary :
Western Blotting (WB)
Uniprot ID :
P29475
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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