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product summary
company name :
Antibodies-online
product type :
antibody
product name :
anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
catalog :
ABIN1107605
quantity :
0.1 mg
price :
313.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SJ-60
reactivity :
human, rat, chicken
application :
western blot, immunohistochemistry, immunoprecipitation
citations: 2
Reference
Hansen J, Bross P, Westergaard M, Nielsen M, Eiberg H, Børglum A, et al. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hum Genet. 2003;112:71-7 pubmed
Cheng M, Hartl F, Martin J, Pollock R, Kalousek F, Neupert W, et al. Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature. 1989;337:620-5 pubmed
product information
Catalog Number :
ABIN1107605
Product Name :
anti-Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1) antibody
Host Species :
Mouse
Clonality :
Monoclonal
Antigen :
HSP60
Product Type :
Primary
Size :
0.1 mg
List Price USD :
313.5 USD
List Of Pubmed ID :
12483302,16767222,2645524
Clone :
SJ-60
Isotype :
IgG1
Product Description :
Heat shock 60KD protein (HSP60) is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNFsecretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.Synonyms: 60 kDa chaperonin, 60 kDa heat shock protein mitochondrial, CPN60, Chaperonin 60, GROEL, GroEL Homolog, HSP-60, HSPD1, Heat shock protein 60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein
Immunogen :
Recombinant human heat shock protein 60 (HSP60)
Reactivity :
Chicken,Human,Rat (Rattus)
Buffer :
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative
Concentration :
0,1 mg/mL
Application Summary :
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunoprecipitation (IP),Western Blotting (WB)
Uniprot ID :
P10809
company information
Antibodies-online
Schloss-Rahe-Str. 15, 52072 Aachen
info@antibodies-online.com
http://www.antibodies-online.com
49 (0)241 95 163 153
headquarters: Germany
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