anti-Toll-Like Receptor 9 (TLR9) (AA 1-815), (Extracellular Domain), (N-Term) antibody (FITC) | Antibodies-online ABIN1106226 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Antibodies-online

product type :

antibody

product name :

anti-Toll-Like Receptor 9 (TLR9) (AA 1-815), (Extracellular Domain), (N-Term) antibody (FITC)

catalog :

ABIN1106226

quantity :

0.1 mg

price :

544.5 USD

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

5G5

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, enzyme immunoassay, immunohistochemistry - frozen section

citations: 7

Reference
Jeong J, Choi M, Cho Y, Lee S, Oh J, Park J, et al. Chronic gastrointestinal symptoms and quality of life in the Korean population. World J Gastroenterol. 2008;14:6388-94 pubmed
Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
Tokumasa N, Suto A, Kagami S, Furuta S, Hirose K, Watanabe N, et al. Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation. Blood. 2007;110:553-60 pubmed
Pratesi G, Petrangolini G, Tortoreto M, Addis A, Belluco S, Rossini A, et al. Therapeutic synergism of gemcitabine and CpG-oligodeoxynucleotides in an orthotopic human pancreatic carcinoma xenograft. Cancer Res. 2005;65:6388-93 pubmed
Rutz M, Metzger J, Gellert T, Luppa P, Lipford G, Wagner H, et al. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol. 2004;34:2541-50 pubmed
Rumio C, Besusso D, Palazzo M, Selleri S, Sfondrini L, Dubini F, et al. Degranulation of paneth cells via toll-like receptor 9. Am J Pathol. 2004;165:373-81 pubmed
Ahmad Nejad P, Hacker H, Rutz M, Bauer S, Vabulas R, Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol. 2002;32:1958-68 pubmed

product information

Catalog Number :

ABIN1106226

Product Name :

anti-Toll-Like Receptor 9 (TLR9) (AA 1-815), (Extracellular Domain), (N-Term) antibody (FITC)

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

FITC

Antigen :

CD289 / TLR9

Product Type :

Primary

Size :

0.1 mg

List Price USD :

544.5 USD

List Of Pubmed ID :

12115616,15307186,15277213,19009657,18439687,16024642,17395783

Clone :

5G5

Isotype :

IgG2a

Product Description :

Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFκB-dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens. Whereas most TLRs are expressed on the cell surface, TLR9 is expressed intracellularly within one or more endosomal compartments and recognizes nucleic acids. TLR9 detects a rather subtle difference in the DNA of vertebrates compared with that of pathogens. Vertebrate genomic DNAs have mostly methylated CpG dinucleotides where bacterial and viral DNAs have unmethylated CpG dinucleotides. TLR9 undergoes relocation from endoplasmic reticulum to CpG-ODN-containing endosomes. In these endosomes TLR9 becomes a functional receptor after proteolytic cleavage. TLR9 exists as a preformed homodimer and CpG-ODN binding promotes its conformational change, bringing the cytoplasmic TIR-like domains close to each other. This allows a recruitment of the key adapter protein MyD88 which initiates a signalling cascade. The only human immune cell types known to constitutively express TLR9 and to be activated by CpG ODN are pDCs and B cells. TLR9 triggering induces an activation phenotype in the B cells and pDCs, characterized by the expression of costimulatory molecules, resistance to apoptosis, and induces Th1-type immune response profiles.Synonyms: Toll-like receptor 9, UNQ5798/PRO19605

Immunogen :

Purified fusion protein of extracellular domain of human TLR9 (AA 1-815) and human IgGFc

Epitope :

AA 1-815,Extracellular Domain,N-Term

Reactivity :

Dog (Canine),Human,Mouse (Murine)

Buffer :

PBS, 1 % bovine serum albumin, 0.02 % sodium azide

Concentration :

0.1 mg/mL

Application Summary :

Enzyme Immunoassay (EIA),Immunofluorescence (IF),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Western Blotting (WB)

Uniprot ID :

Q9EQU3