TREML1/TLT-1 | American Research Products 19-C391 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

TREML1/TLT-1

catalog :

19-C391

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C391

Product Name :

TREML1/TLT-1

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Trem-like transcript 1 protein (TREML1), also called Triggering receptor expressed on myeloid cells-like protein 1 (TLT-1), is a single-pass type I membrane protein. TREML1 precursor contains a 15 sgnal peptide, a 147 aa extracellular domain with a Ig-like V-type (immunoglobulin-like) domain, and 128 aa cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic vesicles in resting platelets. TREML1 be transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. The phosphorylated TREML1 can interact with PTPN6 and PTPN11. TREML1 may participate in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human TREML1 was lyophilized at 1mg/ml in 20mM PBS.