SPARC | American Research Products 19-C388 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

SPARC

catalog :

19-C388

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C388

Product Name :

SPARC

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Secreted protein acidic and rich in cysteine (SPARC), also called Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein and belongs to the SPARC family. SPARC has 286 amino acids and contains an EF-hand in C-termina domain, a follistatin-like domain with Kazal-like sequences. There are two calcium binding sites, one binds 5 - 8 Ca2+ with a low affinity and other on an EF-hand loop that binds a Ca2+ ion with a high affinity. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC regulate cell growth through interactions with the extracellular matrix (ECM) and cytokines. SPARC bind to numerous proteins of the ECM, affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC also binds several types of collagen, albumin, thrombospondin, PDGF and cell membranes.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human SPARC was lyophilized at 1mg/ml in 20mM PBS.