NTB-A/SLAMF6 | American Research Products 19-C387 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

NTB-A/SLAMF6

catalog :

19-C387

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C387

Product Name :

NTB-A/SLAMF6

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

SLAM family member 6, also called Ly108 and Activating NK receptor, NTB-A (NK-T-B-antigen), is a 60 kDa single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 aa extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 aa transmembrane segment and an 84 aa cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a Homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-gamma by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human SLAMF6 was lyophilized at 1mg/ml in 20mM PBS.