This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
American Research Products
product type :
protein
product name :
SIRP alpha/CD172a
catalog :
19-C385
quantity :
10 ug
price :
99.00 USD
product information
Catalog Number :
19-C385
Product Name :
SIRP alpha/CD172a
Product Type :
Recombinant Protein
Size :
10 ug
List Price :
99.00 USD
Product Description :
Signal regulatory protein alpha (SIRPalpha, designated CD172a), also known as Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS-1), CD172 antigen-like family member A, is a monomeric ~90 kDa type I transmembrane glycoprotein. The 504 aa human SIRPA contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPalpha can express in various tissue, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPalpha acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPalpha engagement generally produces a negative regulatory signal, it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Packaging :
Recombinant Human SIRPA was lyophilized at 1mg/ml in 20mM PBS.
company information
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
orders@arp1.com
http://www.arp1.com
(800) 832-2611
headquarters: USA