This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
American Research Products
product type :
protein
product name :
pIgR
catalog :
19-C381
quantity :
10 ug
price :
99.00 USD
product information
Catalog Number :
19-C381
Product Name :
pIgR
Product Type :
Recombinant Protein
Size :
10 ug
List Price :
99.00 USD
Product Description :
The human polymeric immunoglobulin receptor (pIgR), is a 100 kDa type I tran-smembrane glycoprotein. Its precursor has 764 amino acid, contains an 18 aa signal sequence, a 620 aa extracellular region, a 23 aa transmembrane fragment, and a 103 aa cytoplasmic domain. pIgR is synthesized by secretory epithelial cells with five Ig-like domains in extracellular region, and transfer to the basolateral plasma membrane. For IgA and IgM polymers, in addition to alpha-heavy chains and light Ig chains, a short polypeptide named joining chain (J chain) is also contained and required. pIgR can bind larger polymers of IgA (pIgA) and pentameric IgM as as a carrier that transports IgA and IgM across epithelium. The receptor-ligand complexes are endocytosed and transcytosed to the apical surface, then proteolytic cleavage of the sixth extracellular domain of pIgR and generate secretory IgA (SIgA), the pIgR fragment is referred to as secretory component (SC). SIgA is a important component of the mucosal immune system. SC is anti-microbial properties and protects SIgA from proteolytic degradation.
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Packaging :
Recombinant Human pIgR was lyophilized at 1mg/ml in 20mM PBS.
company information
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
orders@arp1.com
http://www.arp1.com
(800) 832-2611
headquarters: USA