PDGF R beta | American Research Products 19-C380 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

PDGF R beta

catalog :

19-C380

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C380

Product Name :

PDGF R beta

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Beta-type platelet-derived growth factor receptor, also known as CD140 antigen-like family member B, CD140b, PDGFRB, PDGF-R-beta, PDGF receptor-beta, is a member of the protein kinase superfamily and CSF-1/PDGF receptor subfamily. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD). The four PDGFs are inactive in their monomeric forms. The PDGFs bind to the protein tyrosine kinase receptors PDGF receptor-alpha and -beta. These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely -alphaalpha, -betabeta and -alphabeta. The extracellular region of the PDGF receptor-beta consists of five immunoglobulin-like domains while the intracellular part is a tyrosine kinase domain. In addition to being a potent mitogen for cells of mesenchymal origin, PDGF has also been shown to be a potent chemoattractant for mesenchymal cells, mononuclear cells, and neutrophils and has been reported to be important in the modification of cellular matrix constituents.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human PDGF RÎ² was lyophilized at 1mg/ml in 20mM PBS.