MMP-12 | American Research Products 19-C375 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

MMP-12

catalog :

19-C375

quantity :

10 ug

price :

149.00 USD

product information

Catalog Number :

19-C375

Product Name :

MMP-12

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

149.00 USD

Product Description :

Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endo-peptidases which degrade components of the extracellular matrix (ECM). MMP-12 (macrophage elastase) is found in macrophages and its expression can be induced by cytokines. MMP 12 plays essential roles in various physiological processes and pathological processes. MMP-12 is responsible for cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be part in tissue injury and remodeling and has significant elastolytic activity. MMP-12 is related to the pathogenesis of aortic aneurysms and in the development of pulmonary emphysemaMMP-12 is a potent proinflammatory and oncogenic molecule MMP-12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human MMP12 was lyophilized at 1mg/ml in 20mM PBS.