IFN-alpha/beta R1 | American Research Products 19-C358 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

IFN-alpha/beta R1

catalog :

19-C358

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C358

Product Name :

IFN-alpha/beta R1

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

The interferon-alpha/beta receptor (IFN-alpha/beta R1) , also known as IFNAR1, is a receptor which binds type I interferons including interferon-alpha and -beta. It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN-alpha/beta R1, in association with IFN-alpha/beta R2, is required for propagating antiviral signal transduction triggered by IFN-alpha and IFN-beta. IFN-alpha/beta R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-alpha/beta R2. Ligands associate with IFN-alpha/beta R2, and this complex subsequently forms a stable ternary assembly with IFN-alpha/beta R1. IFN-alpha/beta R1 also associates with IFN-gamma R2 even in the absence of IFN-gamma stimulation. Human IFN-alpha/beta R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human IFN-Î± was lyophilized at 1mg/ml in 20mM PBS.