CD14 | American Research Products 19-C308 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

CD14

catalog :

19-C308

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C308

Product Name :

CD14

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

CD14,also known as lipopolysaccharide (LPS) receptor,is a cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS binding protein (LBP). The toll like receptors have also been implicated in the transduction of CD14-LPS signals. Soluble CD14 can be released from the cell surface by phosphatidyinositolspecific phospholipase C and has been detected in serum and body fluids.High concentrations of soluble CD14 have been shown to inhibit LPS mediated responses.However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human CD14 was lyophilized at 1mg/ml in 20mM PBS.