Recombinant e.coli G/U mismatch-specific DNA glycosylase/Mug | American Research Products 19-C152 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

American Research Products

product type :

protein

product name :

Recombinant e.coli G/U mismatch-specific DNA glycosylase/Mug

catalog :

19-C152

quantity :

10 ug

price :

149.00 USD

product information

Catalog Number :

19-C152

Product Name :

Recombinant e.coli G/U mismatch-specific DNA glycosylase/Mug

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

149.00 USD

Product Description :

E. coli Mismatch Uracil DNA Glycosylase (Mug protein), also known as G/U mismatch-specific DNA glycosylase, is an 18 kDa constitutively expressed protein which belongs to the TDG/mug DNA glycosylase family. It has been proposed that the Mug protein excises 3,N4-ethenocytosine and removes the uracil base from mismatches in the order of U:G>U:A, although the biological role remains unclear. Uracil bases in DNA can arise from deamination of cytosine giving rise to increased spontaneous mutations. The enzyme Uracil-N-Glycosylase removes uracil from the DNA leaving an AP site. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant e.coli Mug protein was lyophilized at 1mg/ml in 20mM PBS.