protein

IL-20

19-C147

10 ug

149.00 USD

IL-20

Recombinant Protein

10 ug

149.00 USD

Interleukin-20, also known as IL-20, Cytokine Zcyto10, is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 exhibits approximately 28% amino acid (aa) identity with IL-10 and 76% aa identity with mouse IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 Ralpha and IL-20 Rbeta. The second is composed of IL-22 R and IL-20 Rbeta. Whereas the IL-22 R/IL-20 Rbeta complex is shared with IL-24, the IL-20 Ralpha/IL-20 Rbeta complex is shared with both IL-19 and IL-24. IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF-alpha and MCP-1. Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyperproliferation, abnormal epidermal differentiation, and neonatal lethality. In humans, IL-20 and its receptors are upregulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis. IL-20 may also have a role in hematopoiesis. It enhances the proliferation of multipotential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice. IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.

Greater than 95% as determined by reducing SDS-PAGE.

Recombinant Human IL20 was lyophilized at 1mg/ml in 20mM PBS.