protein

CXCL11/I-TAC

19-C119

10 ug

119.00 USD

CXCL11/I-TAC

Recombinant Protein

10 ug

119.00 USD

Chemokine (C-X-C motif) ligand 11 (CXCL11), also known as Interferon-inducible T cell alpha chemoattractant(I-TAC) and Interferon-gamma-inducible protein 9 (IP-9), is a non-ELR(lacking the Glu-Leu-Arg tripeptide motif) CXC chemokine. I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-gamma and IFN-beta, and weakly induced by IFN-alpha. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family. CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence, which is cleaved to form the mature 73 aa residue protein. CXCL11 shares 36% and 37% amino acid sequence homology with IP-10 and MIG (two other known human non-ELR CXC chemokines), respectively. Mouse I-TAC exhibits 68% aa sequence homology with human I-TAC. In humans, I-TAC, IP-10 and MIG all map to the same locus on chromosome 4.

Greater than 95% as determined by reducing SDS-PAGE.

Rcombinant human CXCL11 is lyophilized in PBS