protein

CCL26/Eotaxin-3 24-94

19-C113

10 ug

119.00 USD

CCL26/Eotaxin-3 24-94

Recombinant Protein

10 ug

119.00 USD

Chemokine (C C motif) ligand 26 protein(also known as CCL26, Eotaxin-3 protein, thymus and activation regulated chemokine (TARC) or SCYA26), is a novel small cytokine belonging to the CC chemokine family which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with eotaxin-1 and eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for eotaxin-3 encodes a protein of 94 amino acids (aa) with a putative signal peptide of either 23 or 26 aa residues. Both the 71 and 68 aa residue variants of recombinant eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the eotaxin-2 loci. Eotaxin-3 and eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.

Greater than 95% as determined by reducing SDS-PAGE.

Recombinant Human CCL26 24-94 was lyophilized at 1mg/ml in 20mM PBS.