protein

CXCL2/GRO beta/MIP-2/CINC-3

19-C096

10 ug

149.00 USD

CXCL2/GRO beta/MIP-2/CINC-3

Recombinant Protein

10 ug

149.00 USD

Chemokine (C-X-C motif) ligand 2 (CXCL2), also known as growth-regulated protein beta, Gro-beta, macrophage inflammatory protein 2-alpha, MIP2-alpha, and Gro oncogene-2, GRO2, is a small secreted cytokine which belongs to the CXC chemokine family. CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. CXCL2/MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2. CXCL2/MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is Hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.

Greater than 95% as determined by reducing SDS-PAGE.

Recombinant Human CXCL2 was lyophilized at 1mg/ml in 20mM PBS.