Sonic Hedgehog/Shh C24II | American Research Products 19-C089 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

Sonic Hedgehog/Shh C24II

catalog :

19-C089

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C089

Product Name :

Sonic Hedgehog/Shh C24II

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Sonic hedgehog homolog (SHH) belongs to a three-protein family called hedgehog. The other two family members are Indian Hedgehog (IHH) and Desert Hedgehog (DHH). Hedgehog proteins are key signaling molecules in embryonic development. SHH is expressed in various embryonic tissues and plays critical roles in regulating the patterning of many systems, such as limbs and brain. SHH also plays an important role in adult, including the division of adult stem cells and the development of certain cancers and other diseases. Human SHH is expressed as a 45kDa precursor, and undergoes a series of processing during secretion. After the removal of the signal peptide, a protease within the C-terminal domain catalyzes the cleavage of SHH into a 20 kDa N-terminal signaling domain (SHH-N) and a 25 kDa C-terminal domain (SHH-C). SHH-N has the all signaling capability. SHH-N binds to the 12 pass transmembrane protein Patched (Ptc) on cell surface, which releases the repression of the activity of Smoothened (Smo), a G-protein coupled receptor, by Ptc.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Sonic Hedgehog/Shh C24II was lyophilized at 1mg/ml in 20mM PBS.