Recombinant mouse Complement Component C5/C5a | American Research Products 19-C075 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

Recombinant mouse Complement Component C5/C5a

catalog :

19-C075

quantity :

10 ug

price :

139.00 USD

product information

Catalog Number :

19-C075

Product Name :

Recombinant mouse Complement Component C5/C5a

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

139.00 USD

Product Description :

Mouse Complement 5a (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 77 amino acid (aa) peptide that is created by the C5a convertase proteolytic cleavage of C5 alphachain in the classical and alternative complement pathway (C4b2a3b, C3bBb3b). Mouse C5a has fouralphahelices, plus three intrachain disulfide bonds that form a triple loop structure. C5a functions via G-protein coupled receptor (GPCR) (C5aR/CD88). C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. It mediates IL-8 release from bronchial epithelial cells. It also triggers an oxidative burst in macrophages and neutrophils, causing release of histamine in basophils and mast cells.C5a anaphylatoxin activity on hepatocytes results indirectly from interaction with nonparenchymal cell via prostanoid secretion. Mouse C5a shares 60% and 82% aa sequence identity to human and rat C5a,respectively.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

The protein was lyophilized from a concentrated (1mg/ml) solution in 20mM PB, pH 7.5, 350mM NaCl buffer.