This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
American Research Products
product type :
protein
product name :
IL-36 alpha/IL-1F6
catalog :
19-C072
quantity :
10 ug
price :
149.00 USD
product information
Catalog Number :
19-C072
Product Name :
IL-36 alpha/IL-1F6
Product Type :
Recombinant Protein
Size :
10 ug
List Price :
149.00 USD
Product Description :
Human interleukin family 1, member 6 (hIL-1F6 / FIL1-epsilon), is a secreted cytokine which belongs to the interleukin 1 cytokine family. IL-1F6 is expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. IL-1F6 is the only IL-1 family member found to be expressed on T-cells. IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARgamma expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine. IL-1F6, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFkappaB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-1F6 may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Packaging :
Recombinant Human IL1F6 was lyophilized at 1mg/ml in 20mM PBS.
company information
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
orders@arp1.com
http://www.arp1.com
(800) 832-2611
headquarters: USA