beta-NGF | American Research Products 19-C060 product information

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product summary

company name :

American Research Products

product type :

protein

product name :

beta-NGF

catalog :

19-C060

quantity :

10 ug

price :

99.00 USD

product information

Catalog Number :

19-C060

Product Name :

beta-NGF

Product Type :

Recombinant Protein

Size :

10 ug

List Price :

99.00 USD

Product Description :

Human NGFbeta was initially isolated in the mouse submandibular gland.It is composed of three non covalently linked subunits, alpha, beta, and gamma and exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta-NGF is a neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that beta-NGF is a pleiotropic cytokine which, in addition to its neurotropic activities, may have an important role in the regulation of the immune system.Human NGFbeta shares 90% sequence similarity with mouse protein and shows cross-species reactivity.

Purity :

Greater than 95% as determined by reducing SDS-PAGE.

Packaging :

Recombinant Human Î²-NGF was lyophilized at 1mg/ml in 20mM PBS.