This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
American Research Products
product type :
protein
product name :
CXCL4/PF4
catalog :
19-C055
quantity :
10 ug
price :
119.00 USD
product information
Catalog Number :
19-C055
Product Name :
CXCL4/PF4
Product Type :
Recombinant Protein
Size :
10 ug
List Price :
119.00 USD
Product Description :
Human Chemokine (C-X-C motif) ligand 4 (hCXCL4),also known as Platelet factor 4 (PF4), is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% aa identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Packaging :
Sterile and Lyophilized aliquots with a 0.2um filtered protein solution containing 50mM Tris-HCl pH8.0,150mM NaCl.
company information
American Research Products
135 Beaver Street, Suite 204
Waltham, MA 02452
orders@arp1.com
http://www.arp1.com
(800) 832-2611
headquarters: USA